Professor@School of Biotechnology

Tel: +86-510-85918292

Email: zpshi@jiangnan.edu.cn

Web:

1988/04-1991/03        Ph.D. Nagoya University (JAPAN)

1986/04-1988/03        M.Sc. Nagoya University (JAPAN)

1980/09-1984/07        B.Sc. Beijing University of Chemical Technology (CHINA)

2002/12–present        Professor, Jiangnan University (CHINA)

2001/04–2002/10       Senior Technical Support Engineer, CambridgeSoft Corp   (USA)

1995/06–2001/03       Senior Engineer, Eagle Precision Technologies Inc (CANADA)

1993/08-1994/12        Postdoctoral Fellow, West Virginia   University (USA)

1992/03-1993/06        Postdoctoral   fellow, The University of Texas at Austin (USA)

1991/04-1992/02        Faculty,   Kyushu Institute of Technology, (JAPAN)

My research   interests focus on using automatic theory, intelligent techniques (Artificial   neural network, Fuzzy logical reasoning, Support vector machine, etc.), metabolic   analysis and dynamic models, graph theory, etc. for fermentation processes   optimizations. The following bioprocesses are mainly considered: heterologous   proteins productions by Pichia pastoris; acetone-butanol fermentation;   glutamate fermentation; CPC productions, etc.

1)         Jian Ding, Hongzhen Luo, Fang Xie, Hao Wang,   Meng Xu, Zhongping Shi*. “Electron receptor addition enhances butanol   synthesis in ABE fermentation by Clostridium acetobutylicum”., Bioresource   Technol., http://dx.doi.org/10.1016/j.biortech.2017.09.   010, 2018.

2)         Luqiang Jia, Tingyong Tu, Qiangqiang Huai,   Jiaowen Sun, Shanshan Chen, Xin Li, Zhongping Shi*, Jian Ding. “Enhancing   monellin production by Pichia pastoris at low cell induction concentration   via effectively regulating methanol metabolism patterns and energy   utilization efficiency”, Plos One, 12(10): e0184602, 2017.

3)         Hongzhen Luo, Jingshu Zhang, Hao Wang, Rui   Chen, Zhongping Shi*, Xin Lic , Jian Ding. “Effectively enhancing   acetone concentration and acetone/butanol ratio in ABE fermentation by a   glucose/acetate co-substrate system incorporating with glucose limitation and   C.acetobutylicum/S cerevisiae co-culturing”, Biochem. Eng.   J., 118, 132-142, 2017.

4)         Hongzheng Luo, Laibing Ge, Jingshu Zhang, Jian   Ding, Rui Chen, Zhongping Shi*: “Enhancing   acetone biosynthesis and acetone-butanol-ethanol fermentation performance by   co-culturing Clostridium acetobutylicum/Saccharomyces cerevisiae   integrated with exogenous acetate addition”, Bioresource   Technol., 2015/10, 200, 111-120, 2016.

5)         Hongzhen Luo,   Laibing Ge, Jingshu Zhang, Yanli Zhao, Jian Ding, Zhigang Li, Zhenni He, Rui   Chen, Zhongping Shi*: “Enhancing Butanol Production Under   the Stress Environments of Co-Culturing Clostridium acetobutylicum/Saccharomyces   cerevisiae integrated with Exogenous Butyrate Addition”, Plos One, 10 (10): e0141160, 2015.

6)         Jian Ding, Minjie Gao, Guoli Hou, Kexue Liang,   Ruisong Yu, Zhen Li, Zhongping Shi*: “Stabilizing   porcine interferon-a production by Pichia pastoris with an ethanol on-line   measurement based DO-stat glycerol feeding strategy”,   J. Chem. Technol. Biot, 89(12), 1948-1953, 2014.

7)         Jian Ding, Chunling Zhang, Minjie Gao, Guoli   Hou, Kexue Liang, Chunhua Li, Jianping Ni, Zhen Li, Zhongping Shi*: “Enhanced porcine circovirus Cap protein production by Pichia   pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding   induction strategy”, J. Biotechnol., 177, 35-44, 2014.

8)         Xin Li, Zhongping Shi*, Zhigang Li: “Increasing butanol/acetone ratio and solvents productivity in   ABE fermentation by consecutively feeding butyrate to weaken metabolic   strength of butyrate loop”, Bioprocess Biosyst. Eng., 37, 1609-1616, 2014.

9)         Hongzhen Luo, Jingshu Zhang, Guoqiang Yuan,   Yanli Zhao, Han Liu, Zhenni He, Zhongping Shi*: “Performance   improvement of cephalosporin C fermentation by Acremonium chrysogenum with   DO-Stat based strategy of co-feeding soybean oil and glucose”, Process Biochem., 48, 1822-1830, 2013.

10)     Zhigang Li, Zhongping Shi*, Xin Li, Le Li,   Zhenggang Wang: “Evaluation of high butanol/acetone ratios   in ABE fermentations with cassava by graph theory and NADH regeneration analysis”,   Biotechnol. & Bioprocess Eng., 18(4), 759-769, 2013.

11)     Minjie Gao, Zhen Li, Ruisng Yu, Jianrong Wu, Zhiyong   Zheng, Zhongping Shi*, Xiaobei Zhan,  Chichung Lin: “Methanol/sorbitol co-feeding induction enhanced porcine   interferon-a production by P. pastoris associated with energy   metabolism shift”, Bioprocess   Biosyst. Eng., 35(7), 1125-1136, 2012.

12)   Jian Ding, Yan Cao, Enock Mpofu, Zhongping Shi*:  “A hybrid support vector machine and fuzzy reasoning based   fault diagnosis and rescue system for stable glutamate fermentation”, Chem. Eng. Res. Des., 90, 1197-1207, 2012.