Professor

Tel: 0510-85197582

Email: zwu@jiangnan.edu.cn

Web:

2013.11 – present            Professor, Jiangnan University

2011.11 – 2013.11            Research Scientist, Industrial Research Ltd. New Zealand

2007.07 – 2011.10            Postdoc, Wayne State University

2005.12 - 2007.06        Postdoc,   Karmanos Carcer Institute

2002.09 – 2005.07           Ph.D.  Zhejiang University

Our   group is focused on carbohydrate chemistry, glycobiology, glycoimmunology and   drug discovery. Our major research interests are focused on: (1) complex carbohydrate   synthesis, including chemical and enzymatic synthesis, and their   immunological studies; (2) chemoenzymatic synthesis of glycoconjugates and   their applications in biology and medicine; (3) metabolic glyco-engineering   and cancer vaccine development

1.      X. Cheng, T. Zhu, H. Hong, Z.   Zhou, Z. Wu*, Sortase A-mediated on-resin peptide cleavage and   in situ ligation: an efficient one-pot strategy for the synthesis of   functional peptides and proteins, Org. Chem. Front., 2017, 4,   2058-2062.

2.      X. Zhao, H. Hong, X, Cheng, S, Liu, T, Deng,   Z, Gu, Z. Wu*, One-step   purification and immobilization of extracellularly expressed sortase A by   magnetic particles to develop a robust and recyclable biocatalyst,   Sci. Rep. 2017, 7. 6561, DOI:10.1038/s41598-017-06856-y

3.      Z. Wu*,   X. Cheng , H. Hong , X. Zhao , Z.   Zhou, New potent and selective αvβ₃ integrin ligands: macrocyclic   peptides containing RGD motif synthesized by sortase A-mediated ligation, Bioorg.   Med. Chem. Lett.,   2017, 27, 1911–1913.

4.      X. Zhao, H. Hong, Z. Wu*, Efficient   extracellular expression of transpeptidase sortase A in Pichia Pastoris,   Protein Expr. Puri., 2017, 133,  132-138.

5.    New   Antibiotic Candidates against Helicobacter pylori., S. Wang, S. Cameron, K.   Clinch*, G. Evans, Z. Wu, V.. Schramm*, and P. Tyler*, J. Am. Chem. Soc., 2015,   137, 14275−14280

6.       Z. Wu, X. Guo, J. Gao, Z.   Guo*. Sortase A-mediated chemoenzymatic synthesis of complex   glycosylphosphatidylinositol-anchored protein
  Chem. Commun., 2013, 49, 11689-11691.

7.      Z. Wu, X.   Guo, G. Guo, Z. Guo*. Chemoenzymatic Synthesis of the Human CD52 and CD24   Antigen Analogues
  Org. Lett., 2013, 15, 5906-5908.

8.       X. Guo, Z. Wu（并列第一）,   Z. Guo*. New Method for Site-Specific Modification of Liposomes with Proteins   Using Sortase A-Mediated Transpeptidation , Bioconjugate Chem.,   2012, 23, 650-655.

9.       Z. Wu,   Z. Guo*. Sortase-Mediated Transpeptidation for Site-Specific Modification of   Peptides, Glycopeptides, and Proteins (Review Article)
  J. Carbohydr. Chem. 2012, 31, 48-66.

10.  Z. Wu, X. Guo, Z. Guo*.   Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic   peptides and glycopeptides
  Chem. Commun., 2011, 47, 9218-9220.

11.  Z. Wu, X. Guo, Z. Guo*.   Chemoenzymatic Synthesis of Glycosylphosphatidylinositol-Anchored   Glycopeptide
  Chem. Comm., 2010, 46, 5773-5774.

12.  Z. Wu, X. Guo, Q. Wang,   B. M. Swarts, Z. Guo*. Sortase A-Catalyzed Transpeptidation of   Glycosylphosphatidylinositol Derivatives for Chemoenzymatic Synthesis of   GPI-Anchored Proteins
  J. Am. Chem. Soc. 2010, 132, 1567-1571.

13.  Z. Wu,   J. C. Drach, M. N. Prichard, M. Yanachkova, I. Yanachkov, T. L. Bowlin, J.   Zemlicka*. L-Valine Ester of Cyclopropavir – a New Antiviral Prodrug , Antiviral   Chemistry and Chemotherapy, 2009, 20, 37-46.

14.  Z. Wu,   S. Zhou, J. Zemlicka*. Stereoselective approach to the Z-isomers of   methylenecyclopropane analogues of nucleosides: A new synthesis of anitiviral   synguanol, Nucleosides, Nucleotides & Nucleic Acids, 2009,   28, 165-174.