Professor

Tel: 0510-85918312

Email: zhoujw1982@jiangnan.edu.cn

Web: http://lbbe.jiangnan.edu.cn

2014 – present           Professor, Jiangnan University, School of Biotechnology

2009 - 2014              Assisstant Professor, Associate Professor, Jiangnan University,   School of Biotechnology

2012 – 2013              Postdoctoral Fellow, Harvard University, Department of Chemistry   and Chemical Biology

2006 – 2009               Ph.D., Jiangnan University, School of Biotechnology

2003 – 2006               M.Sc., Huazhong Agricultural University, School of Life   Science and Technology

1999 – 2003               B.Sc., Huazhong Agricultural University, School of Food   Science and Technology

Prof. Zhou’s   research interesting could be mostly covered by the following issues:

1. Metabolic engineering of industrial microorganisms   for the efficient production of keto acids (pyruvic acid and α-ketoglutaric   acid) and plant natural products (flavonoids and L-ascorbic acid), especially   for the establishment of new strategies in fine-tuning of metabolic pathway   and high-throughput screening;

2. Development of strategies related to   carbon-nitrogen balance regulation in eukaryotic microorganisms, especially   on the regulation of up-stream phosphorylation process and down-stream   ubiquitination process, and their applications in metabolic engineering and   synthetic biology fields.

1.             Weiping   Zhang, Guocheng Du, Jingwen Zhou^*, Jian Chen^*. Regulation   of Sensing, Transportation, and Catabolism of Nitrogen Sources in Saccharomyces   cerevisiae. Microbiology and Molecular Biology Reviews, 2018.   82(1). e00040-17

2.           Yongkun   Lv, Song Gao, Sha Xu, Guocheng Du, Jingwen Zhou*, Jian Chen*.   Spatial organization of silybin biosynthesis in milk thistle [Silybum   marianum (L.) Gaertn]. The Plant Journal, 2017. 92(6): 995-1004.

3.           Yongkun   Lv, Xiaozhong Chen, Guocheng Du, Jingwen Zhou*, Jian Chen*. Engineering   of an H₂O₂ auto-scavenging in vivo cascade for   pinoresinol production. Biotechnology and Bioengineering, 2017.   114(9): 2066-2074.

4.           Shenghu   Zhou, Renpeng Ding, Jian Chen, Guocheng Du, Huazhong Li^*, Jingwen   Zhou*. Obtaining a panel of cascade promoter-5′-UTR complexes in   Escherichia coli. ACS Synthetic Biology, 2017. 6(6): 1065-1075；

5.           Jingwen Zhou*, Kui Wang, Sha Xu,   Junjun Wu, Peiran Liu, Guocheng Du, Jianghua Li*, Jian Chen. Identification   of membrane proteins associated with phenylpropanoids tolerance and transport   in Escherichia coli BL21. Journal of Proteomics. 2015, 113:   15-28.

6.           Junjun   Wu, Oliver Yu, Guocheng Du, Jingwen Zhou*, Jian Chen*.   Fine-tuning of fatty acid pathway by synthetic antisense RNA for enhanced   (2S)-naringenin production from L-tyrosine in Escherichia coli. Applied   and Environmental Microbiology. 2014, 80(23):7283-7292.

7.           Saijie   Zhu, Junjun Wu, Guocheng Du, Jingwen Zhou*, Jian   Chen^*. Efficient synthesis of eriodictyol from L-tyrosine in Escherichia   coli.   Applied   and Environmental Microbiology. 2014, 10(80): 3072-3080.

8.           Lili   Gao, Yudong Hu, Jie Liu, Guocheng Du, Jingwen Zhou*,   Jian Chen^*. Stepwise metabolic engineering of Gluconobacter   oxydans WSH-003 for the direct production of 2-keto-L-gulonic acid from   D-sorbitol.   Metabolic Engineering. 2014, 24: 30–37.

9.           Shaohui   Zhao, Xinrui Zhao, Huijun Zou, Jianwei Fu, Jian Chen, Jingwen Zhou^*,   Guocheng Du^*. Comparative proteomic analysis of Saccharomyces   cerevisiae under different nitrogen sources. Journal of Proteomics.   2014,   101: 102-112.

10.        Jingwen Zhou^*, Guocheng   Du, Jian Chen. Novel fermentation processes for manufacturing plant natural   products. Current Opinion in Biotechnology. 2014. 25: 17-23.

11.        Xinrui   Zhao, Guocheng Du^*, Huijun Zou, Jianwei Fu, Jingwen   Zhou^*, Jian Chen. Metabolic engineering   of the regulators in nitrogen catabolite repression to reduce the production   of ethyl carbamate in a model rice wine system. Applied and Environmental   Microbiology. 2014, 80(1): 392-398.

12.        Xinrui   Zhao, Guocheng Du^*, Huijun Zou, Jianwei   Fu, Jingwen Zhou*, Jian Chen. Progress in   preventing the accumulation of ethyl carbamate in alcoholic beverages. Trends   in Food Science & Technology. 2013, 32: 97-107.

13.        Junjun   Wu, Guocheng Du, Jingwen Zhou^*, Jian Chen^*.   Metabolic engineering of Escherichia coli for (2S)-pinocembrin   production from glucose by a modular metabolic strategy. Metabolic   Engineering. 2013. 16:48-55.

14.        Jingwen Zhou, Liming Liu^*, Jian   Chen^*.   Mitochondrial DNA heteroplasmy in Candida glabrata after mitochondrial   transformation. Eukaryotic Cell. 2010, 9(5): 806-814.

15.        Jingwen Zhou, Liming Liu^*,   Zhongping Shi, Guocheng Du, Jian Chen^*. ATP   in Current Biotechnology: Regulation, Application and Perspectives. Biotechnology   Advances. 2009, 27(1): 94-101.