Associate Professor

Tel: +86-510-85918299

Email: kinowu@jiangnan.edu.cn

Web:

2005 – present           Associate Professor, School of Biotech, Jiangnan University

2011 – 2012              Visiting Scholar, Georgia Institute of Technology (USA)

2002 – 2005              PhD, Pukyong National University (Korea)

1999 – 2002              M.Sc., Jiangnan University, China

1994 – 1998              B.Sc., Beijing Institute of Light Industry, China

Sialic acid   related glyans play important roles in nerve development and disease   occurrence (tumor, Alzheimer’s disease, Parkinson disease etc). Also beta 1,3   glucan has lots of biological functions for human. Our work focus on in-depth   study of fermentative production of polysialic acid and curdlan, biomaterial and   nutritional application of PSA and soluble beta 1,3 oligo-glucan.   Representative   academic discoveries include: Constructed a nitrogen nutrition transduction   signal pathway to control the curdlan biosynthesis in Agrobacteria sp;   Control strategy of pH set-up for high yield of PSA with high molecular weight   and high MW stability; synthesis of PSA-chitosan, PSA-HA, PSA-PEG copolymer   for biomedical applications. These studies offer practical application hints   for functional polysaccharide and oligosaccharide. Our goal is to promote and   develop interesting application for PSA oligo-PSA,and oligo-beta 1,3 glucan,   with specific degree of polymerization.

PSA-NCAM and soluble oligo beta 1,3-glucan

[1]     Wu   JR, Fu X, Jiang Y, Ma X, Zhang HT, Zhan   XB. Dipotassium phosphate improves the molecular   weight stability of polysialic acid in Escherichia coli K235 culture   broth.  Bioresour Technol, 2018, 247:30-35.

[2]     Wu JR,   Zhang JB, Wang PP, Zhu L, Gao MJ, Zheng ZY, Zhan XB. Production of   rhamnolipids by semi-solid-state fermentation with Pseudomonas aeruginosa   RG18 for heavy metal desorption. Bioprocess Biosyst Eng, 2017, 40: 1611-19.

[3]     Wu JR, Fu   H, Zhan XB, Zheng ZY, Zhang, HT. Preparation and characterization of a novel   polysialic acid–hyaluronan graft copolymer potential as dermal filler. Int J   Biol Macromol, 2017, 99:692-698.

[4]     Wang   Z, Wu J, Li Zhu, Zhan X. Characterization of xanthan gum produced from   glycerol by a mutant strain Xanthomonas campestris CCTCC M2015714. Carbohyd   Polym, 2016, 157: 521-526.

[5]     Wu JR, Lu   SZ, Zhan XB, Zheng ZY, Zhang HT, Lin CC. Modification with polysialic   acid-PEG copolymer as a new method for improving the therapeutic efficacy of   proteins. Prep Biochem Biotechnol, 2016, 46(8):788-797. IF1.114

[6]     Wang   ZC, Wu JR, Zhu L, Zhan XB. Activation of glycerol metabolism in Xanthomonas   campestris by adaptive evolution to produce a high-transparency and   low-viscosity xanthan gum from glycerol. Bioresour Technol, 2016,   211:390-397.

[7]     Wu JR,   Zhan XB, Zheng ZY, Zhang HT. Synthesis and Characterization of polysialic   acid/carboxymethyl chitosan hydrogel with potential for drug delivery. Russ J   Bioorg Chem, 2015, 41: 562-567.

[8]     Shin   HY, Wu JR, Chen RR. Comparative engineering of Escherichia coli   for cellobiose utilization: hydrolysis versus phosphorolysis. Metab Eng, 2014,24:   9-17.

[9]     Zheng   ZY, Wang SZ, Li GS, Zhan XB., Lin CC, Wu JR, Zhu L. A new polysialic   acid production process based on dual-stage pH control and fed-batch   fermentation for higher yield and resulting high molecular weight product. Appl Microbiol Biotechnol, 2013, 97(6): 2405-12.

[10] Wu   JR,   Yu   LJ, Zhan   XB, Zheng   ZY, Lu J, Lin CC. NtrC-dependent regulatory network for curdlan   biosynthesis in response to nitrogen limitation in Agrobacterium sp.   ATCC 31749. Process Biochem, 2012, 47(11):1552-1558.

[11]  Wu JR, Lin   Y, Zheng ZY, Zhan XB, Lin CC, Shen YQ. Improvement of the CuZn-superoxide dismutase   enzyme activity and stability as therapeutic agent by modification with   polysialic acids. Biotechnol Lett, 2010, 32(12):1939-1945.

[12]  Wu JR, Liu   JL, Zhan XB, Lin CC, Zhao H. Enhancement of polysialic acid yield by   reduction of initial phosphate and feeding of ammonia water with Escherichia   coli CCTCC M208088. Biotechnol   Bioproc Eng, 2010, 15,   4: 657-663.