Associate Professor

Tel: 0510-85918279

Email: chenxs@jiangnan.edu.cn

2017 – present           Visiting Scholar, Department of Chemistry, University   of Nebraska-Lincoln

2014 – present            Associate Professor, Jiangnan University

2012 – 2014               Lecture, Jiangnan University

2006 – 2011               M.Sc. and Ph.D., Jiangnan University

2002 – 2006               B.Sc., Anhui Science and Technology College

Streptomycetes are used to produce the majority of antibiotics,   anti-parasitic agents, herbicides, pharmacologically active metabolites and   several enzymes important in the food and other industries. ε-Poly-L-lysine   (ε-PL), as a secondary metabolite of Streptomyces albulus, has   exhibited excellent antimicrobial activity, high heat stability and good   water solubility as well as non-toxicity. At present, ε-PL is the third   natural food preservative approved by FDA in the worldwide.

Dr. Chen is devoted to enhance the efficiency of ε-PL production   with high titer, high productivity and high yield, so that it will make ε-PL   has great competition advantages than the existed natural preservative (such   as, Nisin, natamycin) and even chemical ones (such as, sodium benzoate,   potassium sorbate). His research work was focused on: (1) Improvement of ε-PL   production by strain mutagenesis, bioprocess optimization and regulation; (2)   Development of novel purification strategies with high efficiency and low   cost; (3) Revealing the physiological mechanism of high ε-PL production in   Streptomyces; (4) Elucidating the ε-PL biosynthesis mechanism in   Streptomyces. Those studies are   all supported by National Science Foundation of China (31671846, 31301556),   Science and Technology Department of Jiangsu Province (BY2016022-25, BY2013015-11,   BE2012616).

[1] Chen XS, Gao Y, Zhen B, Han   D, Zhang JH, Mao ZG^*. Separation and purification of   ε-poly-l-lysine from fermentation broth. Process Biochem, 2016,51(1):134-141.

[2] Zeng X, Chen XS^*,   Ren XD, Wang L, Gao Y, Mao ZG^*.Improved ε-poly-L-lysine   productivity partly resulting from rapid cell growth in cultures using a   glucose-glycerol mixed carbon source. Eng Life Sci 2016,   16, 443-452.

[3] Ren XD, Xu YJ, Zeng X, Chen XS^*,   Tang L, Mao ZG^*. Microparticle-enhanced production of   ε-poly-L-lysine in fed-batch fermentation. RSC Adv, 2015, 5:82138- 82143.

[4] Zhen B, Chen XS^*,   Han D, Mao ZG^*. An alternative method for the decoloration of   ε-poly-L-lysine eluate by macroporous resin in the separation and   purification of ε-poly-L-lysine from fermentation broth. Food Bioprod Process   2015,95:332-338.

[5] Zeng X, Chen XS^*,   Gao Y, Ren XD, Wang L, Mao ZG^*. Continuously high reactive oxygen   species generation decreased the specific ε-poly-l-lysine formation rate in   fed-batch fermentation using glucose and glycerol as a mixed carbon source.   Process Biochem 2015,50 (12):1993-2003.

[6] Sun QX, Chen XS^*,   Ren XD, Mao ZG^*. Improvement of ε-poly-l-lysine production through   seed stage development based on in situ pH monitoring. Appl Biochem   Biotechnol, 2015,175:802-812.

[7] Zeng X, Chen XS^*,   Ren XD, Liu QR, Wang L, Sun QX, Tang L, Mao ZG^*. Insights into the   role of glucose and glycerol as a mixed carbon source in the improvement of   ε-poly-L-lysine productivity. Appl Biochem Biotechnol. 2014,173(8):2211-2224.

[8] Chen XS, Ren XD, Zeng X,   Zhao FL, Tang L, Zhang HJ, Zhang JH, Mao ZG^*. Enhancement of   ε-poly-L-lysine production coupled with precursor L-lysine feeding in   glucose-glycerol co-fermentation by Streptomyces sp. M-Z18. Bioprocess   Biosyst Eng. 2013,36(12):1843-1849.

[9] Chen XS, Mao ZG^*.   Comparison of glucose and glycerol as carbon sources for ε-poly-L-lysine   production by Streptomyces sp. M-Z18. Appl Biochem Biotechnol.   2013,170(1):185-197.

[10] Chen XS, Ren XD, Dong N,   Li S, Li F, Zhao FL, Tang L, Zhang JH, Mao ZG^*. Culture medium   containing glucose and glycerol as a mixed carbon source improves   ε-poly-L-lysine production by Streptomyces sp. M-Z18. Bioprocess Biosyst Eng.   2012,35(3):469-475.