Associate Professor

Tel: 0510-85198566

Email: zhifangzhou@jiangnan.edu.cn

Web:

2016 – present          Associate Professor, Jiangnan University

2015 – 2016              Postdoc, Wayne State University

2009 – 2014               Ph.D, Wayne State University

2005 – 2009               B.S., University of Science and Technology of China

Our   group is focused on carbohydrate chemistry, glycobiology, glycoimmunology and   immunotherapy, and drug discovery. Our major research interests are centered   on: (1) Carbohydrate antigens are abundantly expressed on the surface of   tumor cells and pathogens. They are excellent targets for vaccine   development. One of our research interests is about the development of novel   synthetic carbohydrate-based vaccines against tumor, bacteria, fungi, and so   on.

(2)   Glycoengineering is a hot topic in chemical biology area. The strategy of   glycoengineering is a useful tool for the studies of glycobiology. In our   research, new strategies are developed for glycoengineering and further   applied in biological studies and immunotherapies.

(3)   Another aspect of our research is about chemical and chemoenzymatic synthesis   of natural and unnatural glycans and glycoconjugates and their applications   in biology and medicine.

(15) Zhifang Zhou, Wenzhang Ding, Chen Li, Zhimeng Wu*, Synthesis   and immunological study of a wall teichoic acid-based vaccine against E.   faecium U0317, Journal of Carbohydrate Chemistry, DOI:   10.1080/07328303.2017.1390576

(14) Zhifang Zhou, Han Lin, Chen Li, Zhimeng Wu*, Recent   progress of fully synthetic carbohydrate-based vaccine using TLR agonist as   build-in adjuvant, Chinese Chemical Letters, DOI: http://dx.doi.org/10.1016/j.cclet.2017.09.047

(13) Zhifang Zhou# (contributed equally), Satadru S.   Mandal#, Guochao Liao#, Jiatong Guo, Zhongwu Guo*, Synthesis and Evaluation   of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer   Vaccine, Scientific Reports, 2017, 7: 11403, DOI:10.1038/s41598-017-11500-w

(12) Xiaozhong Cheng, Tao Zhu, Haofei Hong, Zhifang Zhou,   Zhimeng Wu*, Sortase A-mediated on-resin peptide cleavage and in situ   ligation: an efficient one-pot strategy for the synthesis of functional   peptides and proteins, Org. Chem. Front., 2017, 4, 2058-2062.

(11) Jian Gao, Zhifang Zhou, Jiatong Guo, Zhongwu Guo*, Synthesis   of biotin-labelled core glycans of GPI anchors and their application in the   study of GPI interaction with pore-forming bacterial toxins, Chem. Commun.,   2017, 53, 6227-6230

(10) Zhimeng Wu*, Xiaozhong Cheng, Haofei Hong, Xinrui Zhao,   Zhifang Zhou, New potent and selective avb3 integrin ligands: Macrocyclic   peptides containing RGD motif synthesized by sortase A-mediated ligation, Bioorganic   & Medicinal Chemistry Letters, 2017, 27, 1911-1913

(9) Guochao Liao#, Zhifang Zhou# (contributed equally),   Sharad Suryawanshi, Mohabul A. Mondal, Zhongwu Guo^*, Fully   Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines   against Group C Meningitis, ACS Cent. Sci., 2016, 2, 210-218

(8) Guochao Liao#, Zhifang Zhou# (contributed equally),   Jun Liao, Luning Zu, Qiuye Wu,  Zhongwu Guo^*, 6-O-Branched   Oligo-β-glucan-Based Antifungal Glycoconjugate Vaccines, ACS   Infect. Dis., 2016, 2, 123-131

(7) Zhifang Zhou# (contributed equally), Guochao Liao#,   Satadru S. Mandal, Sharad Suryawanshi, Zhongwu Guo^*, A fully   synthetic self-adjuvanting globo H-Based vaccine elicited strong T   cell-mediated antitumor immunity, Chem. Sci., 2015, 6(12): 7112-7121

(6) Guochao Liao#, Zhifang Zhou# (contributed equally),   Zhongwu Guo^*, Synthesis and Immunological Study of   α-2,9-Oligosialic Acid Conjugates as Anti-group C Meningitis Vaccines, Chem.   Comm., 2015, 51: 9647-9650

(5) Guochao, Liao, Srinivas Burgula, Zhifang Zhou,   Zhongwu Guo*, A Convergent Synthesis of 6- O-Branched β-Glucan   Oligosaccharides, Eur. J. Org. Chem., 2015, (13): 2942-2951

(4) Guochao Liao#, Zhifang Zhou# (contributed equally),   Srinivas Burgula, Jun Liao, Cheng Yuan, Qiuye Wu, Zhongwu Guo*, Synthesis and   Immunological Studies of Linear Oligosaccharides of β-Glucan As Antigens for   Antifungal Vaccine Development, Bioconjugate Chem., 2015, 26(3):   466-476

(3) Zhifang Zhou, Guochao Liao, Sergejs Stepanovs,   Zhongwu Guo^*, Quantifying the Efficiency of N-Phenyl-D-mannosamine   to Metabolically Engineer Sialic Acid on Cancer Cell Surface, Journal of   Carohydrate Chemistry, 2014, 33(7-8): 395-407

 (2) Zhifang Zhou# (contributed equally), Mohabul   Mondal#, Guochao Liao#, Zhongwu Guo^*, Synthesis and evaluation of   monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting   glycoconjugate cancer vaccine carriers, Org. Biomol. Chem., 2014,   12(20): 3238-3245

 (1) Qianli Wang, Zhifang Zhou, Shouchu Tang,   Zhongwu Guo*, Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully   Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses   in the Mouse, ACS Chem. Bio., 2012, 7(1): 235-240

专利：

Zhongwu Guo, Guochao Liao, Zhifang Zhou, Mohabul Mondal,   Srinivas Burgula, Novel Synthetic Anticancer, Antifungal, and Antibacterial   Vaccines, 24 March 2016, PCT, WO 2016/044164 A1