Associate Researcher

Tel: 18362379398

Email: cheng.lu@jiangnan.edu.cn

Web: CollagenLab

2016 – present    Associate Researcher,   Jiangnan University, School of Biotechnology

2011 – 2015      Ph.D.,   University of Freiburg

2008 – 2011     M.Sc.,   China University of Petroleum

2004 – 2008     B.Sc., Binzhou   University

The most   complex and thus, in my opinion, physically most interesting soft matter

systems are   of biological nature. Due to their especially high complexity almost

all studies   of such systems require numerical approches. I use molecular dynamics

(MD)   simulations which allow to investigate bio-mimetic systems consisting of

several ten   thousands of atoms on microsecond timescals in (near) atomic detail

depending on   the model. My research shall focus on：

1). Molecular   Dynamics Explorations of Bio-catalytic Evolution in Enzyme;

2).   Computational Design of novel Collagen Heterotrimer with a Specific Chain   Registry.

1. Lu, Cheng and Knecht,   Volker and Stock, Gerhard. Mechanisms for Allosteric

Activation   of a Protease by Ligand Binding and Oligomerization as Revealed from

Molecular   Dynamics Simulations. Proteins Structure Function and Bioinformatics

84, 2016.

2. Lu, Cheng and Knecht, Volker and   Stock, Gerhard. Long-range conformational

response of   a PDZ domain to ligand binding and release: a molecular dynamics

study,   Journal of Chemical Theory and Computation 12, 2016.

3. Lu, Cheng and Prada-Gracia, Diego   and Rao, Francesco. Structure and dynamics

of water in   crowded environments slows down peptide conformational changes,

Journal of   Chemical Physics 141, 2014.