Associate Professor

Tel:

Email: bobozhang@jiangnan.edu.cn

Web:

Jan 2012 – present      Associate Professor, Jiangnan University

Jun   2014–Jan 2016   Postdoc, University of Namur, group of Prof. Bao-Lian Su   (Member of the Royal Academy of Belgium)

Aug 2008–Dec 2011     Ph.D., The Chinese University of Hong Kong

Sep 2005–Jul 2008       M.Sc., South China University of Technology

Sep 2001–Jul 2005       B.Sc., South China University of Technology

1. Biosynthesis/bioproduction   of valuable metabolites by microbial fermentation

–   Natural Food additives: Red/yellow/orange pigments produced by   submerged/solid-state fermentation of Monascus spp.

–   Functional ingredients: Mushroom polysaccharides

–   Pharmaceuticals: Anticancer/hepatoprotective/etc. metabolites in edible and   medicinal fungi such as Antrodia camphorata

2. Bio-hybrid   materials & Biocatalysis

–   Production of value-added metabolites by bio-hybrid materials, such as   production of recombinant protein by immobilized microalgae

–   Asymmetric synthesis of chiral drugs or their precursors by microbial cells

1. 2016-2020, National Key Research and Development   Program of China (Grant No. 2016YFD0400802), Study on the industrial   production of Monascus natural yellow pigments, Principal   Investigator

2. 2014-2016, National Natural Science Foundation of   China (Grant No. 21306065), A mechanistic study on the metabolic regulation   of Antroquinonol biosynthesis in the mycelia of Antrodia camphorata, Principal   Investigator

3. 2013-2016, Natural Science Foundation of Jiangsu   Province (Grant No. BK20130134), Proteomics based study on the biosynthesis   of bioactive metabolites by submerged fermentation of Antrodia camphorata,   Principal Investigator

4. 2016-2017, the fund of   Beijing Engineering and Technology Research Center of Food Additives,   Green production of natural yellow pigments by fermentation of Monascus spp.   Principal Investigator

5. 2016-2018, Cooperation project with Industrial   Company, Research and development of the extraction and refining technology   for Monascus yellow pigments, Principal Investigator

6. 2013-2016, Cooperation project with Industrial   Company, Separation and purification of bioactive compounds from Antrodia   camphorata, Principal Investigator

7. 2012-2014, Fundamental Research Funds for the   Central Universities (Grant No. JUSRP11219), Study on the production of   bioactive polysaccharide by submerged fermentation of Antrodia camphorata,   Principal Investigator

8. 2014-2016, EU FOTOBIOMAT program (Grant No.   1117323), Développement intégré de matériaux hybrides photosynthétiques par   encapsulation de microalgues en vue de la production en photobioréacteur de   métabolites à haute valeur ajoutée, Participated

9. 2012-2014, National High Technology Research and   Development Program of China (863 Program), Solid fermentation process   control and intelligent equipment and technology, Participated

1. Bo-Bo Zhang*, Li Wang, Valérie Charles,   Joanna C. Rooke, Bao-Lian Su*, Robust and biocompatible hybrid matrix with   controllable permeability for microalgae encapsulation, ACS Applied Materials   & Interfaces, 2016, 8: 8939–8946.

2. Li Wang, Zhi-Yi Hu, Xiao-Yu Yang*, Bo-Bo   Zhang*, Wei Geng, Gustaaf Van Tendelooce, Bao-Lian Su*, Polydopamine   nanocoated whole-cell asymmetric biocatalyst. Chemical Communications, 2017,   53, 6617–6620.

3. Bo-Bo Zhang, Peter C K Cheung*. A   mechanistic study of the enhancing effect of Tween 80 on the mycelial growth   and exopolysaccharide production by Pleurotus tuber-regium.   Bioresource Technology, 2011, 102: 8323–8326.

4. Yong-Dan Hu, Bo-Bo Zhang*, Gan-Rong Xu,   Xiang-Ru Liao*, Peter C.K. Cheung, A mechanistic study on the biosynthetic   regulation of bioactive metabolite Antroquinonol from edible and medicinal   mushroom Antrodia camphorata. Journal of Functional Foods, 2016, 25:   70–79.

5. Bo-Bo Zhang, Peter C K Cheung*. Use of   stimulatory agents to enhance the production of bioactive exopolysaccharide   from Pleurotus tuber-regium by submerged fermentation. Journal of   Agricultural and Food Chemistry, 2011, 59: 1210-1216.

6. Bo-Bo Zhang, Lei Chen, Peter C K Cheung*.   Two-dimensional gel electrophoresis analysis of mycelial cells treated with   Tween 80: Differentially expressed protein related to enhanced metabolite   production. Journal of Agricultural and Food Chemistry, 2012, 60:   10585–10591.

7. Bo-Bo Zhang, Jing Cheng, Wen-Yong Lou, Pan   Wang, Min-Hua Zong*. Efficient anti-Prelog enantioselective reduction of   acetyltrimethylsilane to (R)-1-trimethylsilylethanol by immobilized Candida   parapsilosis CCTCC M203011 cells in ionic liquid-based biphasic systems.   Microbial Cell Factories, 2012, 11: 108–120.

8. Bo-Bo Zhang, Li-Ping Lu, Gan-Rong Xu*. Why   solid-state fermentation is more advantageous over submerged fermentation for   converting high concentration of glycerol into Monacolin K by Monascus   purpureus 9901: A mechanistic study. Journal of Biotechnology, 2015, 206,   60–65.

9. Bo-Bo Zhang, Li-Ping Lu, Yong-jun Xia,   Yuan-Long Wang, Gan-Rong Xu*. Use of agar as carrier in solid-state   fermentation for Monacolin K production by Monascus: a novel method   for direct determination of biomass and accurate comparison with submerged   fermentation. Biochemical Engineering Journal, 2013, 80: 10-13.

10. Huan Zhang, Yong-Dan Hu, Rui-Qiu Lu, Yong-jun   Xia, Bo-Bo Zhang*, Gan-Rong Xu*. Integrated strategy of pH‑shift   and glucose feeding for enhanced production of bioactive Antrodin C in   submerged fermentation of Antrodia camphorata. Journal of Industrial   Microbiology & Biotechnology, 2014, 41: 1305–1310.

11. Yong-Dan Hu, Huan Zhang, Rui-Qiu Lu, Xiang-Ru   Liao, Bo-Bo Zhang*, Gan-Rong Xu*. Enabling the biosynthesis of   Antroquinonol in submerged fermentation of Antrodia camphorata.   Biochemical Engineering Journal, 2014, 91: 157-162.

12. Huan Zhang, Yong-jun Xia, Yuan-Long Wang, Bo-Bo   Zhang*, Gan-Rong Xu*. Coupling use of surfactant and in situ extractant   for enhanced production of Antrodin C by submerged fermentation of Antrodia   camphorata. Biochemical Engineering Journal, 2013, 79: 194-199.

13. Bo-Bo Zhang, Wen-Yong Lou, Wen-Jing Chen,   Min-Hua Zong*. Efficient asymmetric reduction of   4-(trimethylsilyl)-3-butyn-2-one by Candida parapsilosis cells in an   ionic liquid-containing system. PLoS ONE, 2012, 7: e37641

14. Bo-Bo Zhang, Lei Chen, Peter C K Cheung*.   Proteomic insights into the stimulatory effect of Tween 80 on mycelial growth   and exopolysaccharide production of an edible mushroom Pleurotus   tuber-regium. Biotechnology Letters, 2012, 34: 1863-1867.

15. Bo-Bo Zhang, Wen-Yong Lou, Min-Hua Zong*,   Hong Wu. Efficient synthesis of enantiopure   (S)-4-(trimethylsilyl)-3-butyn-2-ol via asymmetric reduction of   4-(trimethylsilyl)-3-butyn-2-one with immobilized Candida parapsilosis   CCTCC M203011 cells. Journal of Molecular Catalysis B- Enzymatic, 2008, 54:   122-129.

16. Yong-Hui Wang, Bo-Bo Zhang*, Li-Ping Lu,   Yan Huang, Gan-Rong Xu*. Enhanced production of pigments by addition of   surfactants in submerged fermentation of Monascus purpureus H1102.   Journal of the Science of Food and Agriculture, 2013, 93: 3339–3344.

17. Jun Zhang, Yuan-Long Wang, Li-Ping Lu, Bo-Bo   Zhang*, Gan-Rong Xu*. Enhanced production of Monacolin K by addition of   precursors and surfactants in submerged fermentation of Monascus purpureus   9901. Biotechnology and Applied Biochemistry, 2014, 61: 202–207.

18. Yong-Dan Hu, Rui-Qiu Lu, Xiang-Ru Liao, Bo-Bo   Zhang*, Gan-Rong Xu*. Stimulating the biosynthesis of antroquinonol by   addition of effectors and soybean oil in submerged fermentation of Antrodia   camphorata. Biotechnology and Applied Biochemistry, 2016, 63: 398–406.

19. Jun Lv, Bo-Bo Zhang*,   Xiao-Dong Liu, Chan Zhang, Lei Chen, Gan-Rong Xu, Peter C.K. Cheung, Enhanced   production of natural yellow pigments from Monascus purpureus by   liquid culture: The relationship between fermentation conditions and mycelial   morphology. Journal of Bioscience and Bioengineering, 2017, 124, 452–458.

1. Professional membership

Member   of the Institute of Food Technologists (IFT), As Reviewer for many academic journals,   such as Biotechnology Advances, Journal of Agricultural and Food Chemistry,   and Process Biochemistry, etc.

2. Responsibility for international academic   activities

Coordinator   for EU FOTOBIOMAT project (Grant No. 1117323), Committee member for 3th   International Conference on Advanced Complex Inorganic Nanomaterials, etc.

3. Oral presentation

IFT   Annual Meeting & Food Expo, 5th Cross-Strait Symposium on Food and   Biotechnology, 1st International Symposium of Food Science and Human   Wellness, 25th Annual Meeting of the Thai Society for Biotechnology and   International Conference, International Symposium on New Frontiers in   Microbiology and Biotechnology, etc.

Teaching

1. Undergraduate   courses

2012-2016 Fermentation engineering: Principles and   Techniques

2012-2016   Technologies of Fermented Foods

2. As   supervisor

Currently   as a supervisor of four postgraduate students

Eight   students have graduated, two students won the National Scholarship Awards and   one of them won the Excellent postgraduate degree thesis of Jiangsu Province