Associated Professor

Tel: +86 510 85329272

Email: wluo@jiangnan.edu.cn

Web:

2011 – present            Associated Professor, Jiangnan University

2005 – 2011               M.Sc. and Ph.D., Zhejiang University

2001 – 2005               B.Sc., Anhui Normal University

Our   group has been engaged in industrial microbial breeding, systems metabolic   engineering and biocatalysis/biotransformation. The main research fields are   as follows,

(1)   Systems metabolic engineering is carried out based on the technologies of   system biology and synthetic biology. The biosynthesis of active products and   the mechanism of metabolic regulation are analyzed for the native microbe. If   this microorganism is suitable for production, metabolic engineering   technologies will be used to reform them, so as to efficiently synthesize   biochemicals. If not, engineering bacteria such as Escherichia coli or   Saccharomyces cerevisiae are constructed through reconstruction of   metabolic pathway to make efficient synthesis of bioactive components, such   as β-carotenoid and lycopene.

  (2) With   the help of gene mining and directed evolution technologies, we want to   screen and obtain enzyme genes with high catalytic activity and other   excellent properties. The highly efficient biocatalysts are prepared by   heterologous expression in the model microorganism, and the efficient   transformation and synthesis of biochemicals, including chiral amino acids, functional   peptides, antiviral nucleoside (acid) drugs, and oligosaccharides   are carried out using the biocatalysts.

1. Wei Luo*,   Zunyang Gong, Xiangnan Zhong, Yao Du, Lankun Zhao, Chuangao Xu, Xiaobin Yu. A   negative regulator of carotenogenesis in Blakeslea trispora. Fungal   Genetics and Biology, 2018, in press

2. Wei   Luo*, Zhangmin Zhao, Hepeng Pan, Lankun Zhao, Chuangao Xu, Xiaobin Yu.   Acetone, butanol, and ethanol production from wheat starch wastewater.   Energy, 2018, in press

3. Zunyang   Gong, Wei Luo*, Yao Du, Xiaobin Yu. Regulation effect of crgA   on carotenoid production in Blakeslea trispora. Acta Microbiologica   Sinica, 57(10): 1527-1535, 2017

4. Zunyang   Gong, Wei Luo*, Yao Du, Miaowen Cheng, Xiangnan Zhong, Ya Zhou, Yu   Xiaobin. Research process on a negative regulator of carotenoid biosynthesis   in filamentous fungi. Journal of Chinese Institute of Food Science and   Technology, 17(5): 144-151, 2017

5. Miaowen   Cheng, Wei Luo*, Yao Du. A new generation of targeted gene   modification technology guided by CRISPR/CAS system and the application in industrial   microorganism. Acta Microbiologica Sinica, 57(11): 1621-1633, 2017

6. Han-guang   Li, Xing-xing Ma, Qing-hua Zhang, Wei Luo, Ya-qing Wu, Xunhang Li.   Enhanced butanol production by solvent tolerance Clostridium   acetobutylicum SE25 from cassava flour in a fibrous bed bioreactor.   Bioresource Technology, 221: 412-418, 2016

7. Han-guang   Li, Qing-hua Zhang, Xiao-bin Yu, Wei Luo, Qiang Wang. Enhancement of   butanol production in Clostridium acetobutylicum SE25 through   accelerating phase shift by different phases pH regulation from cassava   flour. Bioresource Technology, 201: 148-155, 2016

8. Wei   Luo*, Qiuya Gu, Wenting Chen, Xiangcheng Zhu, Zhibing Duan, Xiaobin Yu.   Biodegradation of acetochlor by a newly isolated Pseudomonas strain. Applied   Biochemistry and Biotechnology, 176:636-644, 2015

9. Qiang   Wang, Lingran Feng, Wei Luo, Hanguang Li, Ya Zhou, Xiaobin Yu. Effect   of inoculation process on lycopene production by Blakeslea trispora in   a stirred-tank reactor. Applied Biochemistry and Biotechnology, 175: 770-779,   2015

10. Qiang   Wang, Ling-ran Feng, Wei Luo, Han-guang Li, Lin Wang, Ya Zhou,   Xiao-bin Yu. Mutation breeding of lycopene-producing strain Blakeslea   trispora by a novel atmospheric and room temperature plasma (ARTP).   Applied Biochemistry and Biotechnology, 174: 452-460, 2014

11. Han-guang   Li, Wei Luo, Qiang Wang, Xiao-bin Yu. Direct fermentation of   gelatinized cassava starch to acetone, butanol, and ethanol using Clostridium   acetobutylicum mutant obtained by atmospheric and room temperature   plasma. Applied Biochemistry and Biotechnology, 172(2): 3330-3341, 2014

12. Wei   Luo*, Xiangcheng Zhu, Wenting Chen, Zhibing Duan, Lin Wang, Ya Zhou.   Mechanisms and strategies of microbial cometabolism in the degradation of   organic compounds--chlorinated ethylenes as the model. Water Science and   Technology, 69(10): 1971-1983, 2014

13. Wei Luo*, Jie Wang,   Xb Liu, Hanguang Li, Hepeng Pan, Qiuya Gu, Xiaobin Yu*. A facile and   efficient pretreatment of corncob for bioproduction of butanol. Bioresource   Technology, 140: 86-89, 2013

14. Wei   Luo, Jin Huang, Xiangcheng Zhu, Lei Huang, Jin Cai, Zhinan Xu. Enhanced production   of L-tryptophan with glucose feeding and surfactant addition and related   metabolic flux redistribution in the recombinant Escherichia coli, Food   Science and Biotechnology, 22(1): 207-214, 2013

15. Wei   Luo#, Xiao-Bo Liu#, Qiu-Ya Gu, and Xiao-Bin Yu. Enhancement of butanol   tolerance and butanol yield in Clostridium acetobutylicum Mutant NT642   obtained by nitrogen ion beam implantation.Journal of Microbiology, 51(1):   145, 2013 (#Co-first author)

16. Han-guang   Li, Wei Luo, Qiu-ya Gu, Qiang Wang, Wen-jun Hu, Xiao-bin Yu. Acetone,   butanol, and ethanol production from cane molasses using Clostridium   beijerinckii mutant obtained by combined low-energy ion beam implantation   and N-methyl-N-nitro-N-nitrosoguanidine induction. Bioresource Technology,   137: 254-260, 2013

17. Qiang   Wang, Wei Luo, Qiu-ya Gu, Ling-ran Feng, Han-guang Li, Xiao-bin Yu.   Enhanced lycopene content in Blakeslea trispora by effective   mutation-screening method. Applied Biochemistry and Biotechnology, 171:   1692-1700, 2013

18. Wei   Luo, Jin Cai, Linqi Zhu, Xiangcheng Zhu, Lei Huang, Zhinan Xu, Peilin   Cen. Toxic effects of acrylic acid on Clostridium propionicum and   isolation of acrylic acid-tolerant mutants for production of acrylic acid.   Engineering in Life Sciences, 12(5): 567-573, 2012

19. Wei   Luo, Yunping Liu, Xiangcheng Zhu, Weijun Zhao, Lei Huang, Jin Cai, Zhinan   Xu, Peilin Cen. Cloning and characterization of purine nucleoside   phosphorylase in Escherichia coli and subsequent ribavirin   biosynthesis using immobilized recombinant cells. Enzyme and Microbial   Technology, 48, 438-444, 2011

20. Wei   Luo, Hao Chen, Limei Fan, Jin Huang, Lei Huang, Zhinan Xu, Peilin Cen.   Adsorption behavior of L-tryptophan by ion exchange resin. Korean Journal of   Chemical Engineering, 28(5):1272-1279, 2011

21. Wei   Luo, Peilian Wei, Hao Chen, Limei Fan, Lei Huang, Jin Huang, Zhinan Xu,   Peilin Cen. Kinetics and optimization of L-tryptophan separation with   ion-exachange chromatography. Korean Journal of Chemical Engineering, 28(5):   1280-1285, 2011

22. Wei   Luo, Yuhua Zhao, Haitao Ding, Xiaoyan Lin, Huabao Zheng. Co-metabolic   degradation of bensulfuron-methyl in laboratory conditions. Journal of   Hazardous Materials, 158, 208-214, 2008