Associate Professor

Tel: 86-510-85197571

Email: haiquanyang@jiangnan.edu.cn

Web:

2015 – present    Associate  professor,   Jiangnan University, School of Biotechnology.

2013 – 2015       Lecture, Jiangnan University

2008 – 2013       Ph.D Fellow,   Jiangnan University

2003 – 2007     B.Sc. ,   Shandong Institute of Light Industry

Main research   interesting on the two areas, Enzyme Engineering and Extracellular Production,   and Microbial Engineering.

1. Ma,   Yingfang; Shen, Wei; Chen, Xianzhong; Liu, Long; Zhou, Zhemin; Xu, Fei; Yang   Haiquan*. Significantly enhancing recombinant alkaline amylase production   in Bacillus subtilis by integration of a novel mutagenesis-screening   strategy with systems-level fermentation optimization. Journal of Biological   Engineering, 2016, 10: 13

2. Yang   Haiquan, Liu Long, Xu Fei*.   The   promises and challenges of fusion constructs in protein biochemistry and   enzymology. Applied Microbiology and Biotechnology, 2016, 100(19): 8273-8281.

3. Guo Wenwen, Yang Haiquan*, Qiang   Shumin, Fan You, *Shen Wei, *Chen Xianzhong. Overproduction, purification,   and properties analysis of an extracellular recombinant fructosyltransferase.   European Food Research and Technology. 2016, 242(7): 1159-1168.

4. Ma Yingfang, Yang Haiquan*, Chen   Xianzhong, Sun Bo, Du Guocheng, Zhou Zhemin, *Song Jiangning, Fan You, *Shen   Wei. Significantly improving the yield of recombinant proteins in Bacillus   subtilis by a novel powerful mutagenesis tool (ARTP): Alkaline α-amylase   as a case study. Protein Expression and Purification. 2015, 114: 82-88.

5. Yang   Haiquan; Li, Jianghua;   Shin, Hyun-Dong; Du, Guocheng; Liu, Long; Chen, Jian. Molecular engineering   of industrial enzymes: recent advances and future prospects. Applied   Microbiology and Biotechnology, 2014, 98(1): 23-29.

6. Yang   Haiquan; Liu, Long; Shin,   Hyun-dong; Chen, Rachel R; Li, Jianghua; Du, Guocheng; Chen, Jian. Integrating   terminal truncation and oligopeptide fusion for a novel protein engineering   strategy to improve specific activity and catalytic efficiency: alkaline   alpha-amylase as a case study. Applied and Environmental   Microbiology, 2013, 79(20), 6429-6438.  

7. Yang   Haiquan; Lu, Xinyao; Liu,   Long; Li, Jianghua; Shin, Hyun-dong; Chen, Rachel R; Du, Guocheng; Chen, Jian.   Fusion of an oligopeptide to the N terminus of an   alkaline alpha-amylase from Alkalimonas amylolytica simultaneously   improves the enzyme's catalytic efficiency, thermal stability, and resistance   to oxidation. Applied and Environmental Microbiology,   2013, 79(9), 3049-3058.

8. Yang   Haiquan; Liu, Long; Shin, Hyun-dong; Li, Jianghua; Du, Guocheng; Chen,   Jian. Structure-guided systems-level engineering of oxidation-prone   methionine residues in catalytic domain of an alkaline alpha-amylase from   Alkalimonas amylolytica for significant improvement of both oxidative   stability and catalytic efficiency. PLoS One, 2013, 8(3), e57403.

9. Yang   Haiquan; Long Liu;   Hyun-dong Shin; Rachel R. Chen; Jianghua Li; Guocheng Du; Jian Chen. Structure-based   engineering of histidine residues in the catalytic domain of α-amylase from Bacillus   subtilis for improved protein stability and catalytic efficiency under   acidic conditions. Journal of Biotechnology, 2013, 164(1),   59-66.

10. Yang   Haiquan; Liu, Long; Wang,   Mingxing; Li, Jianghua; Wang, Nam Sun; Du, Guocheng; Chen, Jian. Structure-based engineering of methionine residues in the   catalytic cores of alkaline amylase from Alkalimonas amylolytica for   improved oxidative stability. Applied and Environmental Microbiology,   2012, 78(21), 7519-7526