Associate Professor  Ruizhi Han

Tel: +86-18261541586

Email:  hanrz@jiangnan.edu.cn

Web: http://biocat.jiangnan.edu.cn/

2014 –present            Associate Professor, Jiangnan University

2010 – 2014               Ph.D., Jiangnan University

2007 – 2010               M.Sc., Sichuan University

2003 – 2007               B.Sc., Hefei University of Technology

Dr. Ruizhi   Han is focused on in-depth study of protein engineering   and enzyme engineering, e.g. cyclodextrin glycosyltransferase (CGTase) and   sucrose phosphorylase (SPase). He has published many papers in some   international authoritative journals such as Biotechnol Adv, Appl Environ   Microbiol and Appl Microbiol Biotechnol. He was awarded excellent doctorate   theses of Jiangsu Province in 2015, and “the supreme good young scholars of Jiangnan   University” in 2015 and 2016. He has achieved the fund assistance from the   National Natural Science Foundation of China and Natural Science Foundation   of Jiangsu Province.

1.         Rui-Zhi Han, Guo-Chao Xu, Jin-Jun Dong, Ye   Ni*. Arginine deiminase: recent advances in   discovery, crystal structure, and protein engineering for improved properties   as an anti-tumor drug. Applied Microbiology & Biotechnology   (2016) 100: 4747-4760

2.         Rui-Zhi Han, Guo-Chao Xu, Jin-Jun Dong, Ye Ni*. Arginine deiminase: recent advances in discovery,   crystal structure, and protein engineering for improved properties as an   anti-tumor drug. Applied Microbiology & Biotechnology (2016)   100: 4747-4760

3.         Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Recent advances in discovery,   heterologous expression, and molecular engineering of cyclodextrin   glycosyltransferase for versatile applications. Biotechnology Advances, 32, 415-428.  

4.         Han, R.Z., Li, J.H., Shin, H.D. et al. (2014) Fusion of self-assembling amphipathic   oligopeptides with cyclodextrin glycosyltransferase improves   2-O-D-glucopyranosyl-l-ascorbic acid synthesis with soluble starch as the   glycosyl donor. Applied and Environmental Microbiology, 80, 4717-4724.

5.         Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Iterative saturation   mutagenesis of -6 subsite residues in cyclodextrin glycosyltransferase from   Paenibacillus macerans to improve maltodextrin specificity for   2-O-d-glucopyranosyl-l-ascorbic acid synthesis. Applied and Environmental   Microbiology, 79, 7562-7568.

6.         Han, R.Z., Li, J.H., Shin, H.D. et al. (2013) Carbohydrate-binding   module-cyclodextrin glycosyltransferase fusion enables efficient synthesis of   2-O-d-glucopyranosyl-l-ascorbic acid with soluble starch as the glycosyl   donor. Applied and Environmental Microbiology, 79, 3234-3240.

7.         Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Systems engineering of   tyrosine 195, tyrosine 260, and glutamine 265 in cyclodextrin   glycosyltransferase from Paenibacillus macerans to enhance maltodextrin   specificity for 2-O-(D)-glucopyranosyl-(L)-ascorbic acid synthesis. Applied   and Environmental Microbiology, 79, 672-677.

8.         Han, R.Z., Liu, L., Shin, H.D. et al. (2013) Site-saturation engineering of   lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans to   enhance substrate specificity towards maltodextrin for enzymatic synthesis of   2-O-D-glucopyranosyl-L-ascorbic acid (AA-2G). Applied Microbiology and   Biotechnology, 97, 5851-5860.

9.         Han, R.Z., Liu, L., Li, J.H. et al. (2012) Functions, applications and   production of 2-O-D-glucopyranosyl-L-ascorbic acid. Applied Microbiology and   Biotechnology, 95, 313-320.