Associate Professor

Tel: +86-510-85197071

Email: wangning@jiangnan.edu.cn

Web: http://klccb.jiangnan.edu.cn/info/1005/1211.htm

2016 – present            Associate Professor, Jiangnan University

2015 – 2016               Postdoctoral Fellow, RIKEN (Japan)

2013 – 2015               Researcher, Japan Science and Technology Agency (Japan)

2011 – 2013               JSPS Research Fellow, Japan Society   for the Promotion of Science (Japan)

2009 – 2012               Ph.D., Osaka University (Japan)

2006 – 2009               M.Sc., Peking University

2002 – 2006               B.Sc., Peking University

N-Linked   glycosylation is a major post-translational modification of secretory or   membrane proteins in eukaryotes, which plays important roles in countless   biological processes. Wang’s general research interests are to investigate   the synthetic methodology and biological function of N-glycans as well as the   protein glycosylation related enzymes. Currently, the projects are focusing   on in vitro preparation of various human N-glycans, by developing   novel chemo-enzymatic methodologies. In this process, functional and   structural analyses of involved glycosyltransferases and glycosidases are   also performed. These studies will offer different types of N-glycans, providing   useful substrates and tools for scientific studies of glycosyltransferases, glycoproteins   and pharmaceutical applications.

Selected original papers:

1. N. Wang, S-T. Li,   T-T. Lu, H. Nakanishi, X-D. Gao Approaches towards the core pentasaccharide   in N-linked glycans. Chinese Chemical Letters, 2017, DOI:10.1016/j.cclet.2017.09.044.

2. N. Wang, H.   Hasegawa, C-y. Huang, K. Fukase, Y. Fujimoto Synthesis of peptidoglycan   fragments from Enterococcus faecalis with Fmoc-strategy for glycan   elongation. Chem. Asian J. 2017, 12, 27.

3. S-T. Li, N. Wang,   S. Xu, J. Yin, H. Nakanishi, N. Dean, X-D. Gao Quantitative study of yeast   Alg1 beta-1, 4 mannosyltransferase activity, a key enzyme involved in protein   N-glycosylation. BBA-General Subjects 2017, 1861, 2934.

4. N. Wang, A.   Seko, S. Daikoku, O. Kanie, Y. Takeda, Y. Ito Non-enzymatic reaction of   glycosyl oxazoline with peptides. Carbohydrate Research 2016, 436,   31.

5. N. Wang, A.   Hirata, K. Nokihara, K. Fukase, Y. Fujimoto Peptidoglycan microarray as a   novel tool to explore protein-ligand recognition. Biopolymers 2016,   106, 422.

6. N. Wang, A.   Seko, Y. Tekeda, T. Kikuma, Y. Ito Cooperative role of Calnexin and TigA in Aspergillus   oryzae glycoprotein folding. Glycobiology 2015, 25,   1090.

7. N. Wang, A.   Seko, Y. Tekeda, Y. Ito Preparation of asparagine-linked monoglucosylated   high-mannose-type oligosaccharide from egg yolk. Carbohydrate Research   2015, 411, 37.

8. S. Mesnage, M.   Dellarole, N. Baxter, J. Rouget, J. Dimitrov, N. Wang, Y. Fujimoto, A   Hounslow, S. Lacroix-Desmazes, K. Fukase, S. Foster, M. Williamson Molecular   basis for bacterial peptidoglycan recognition by LysM domains. Nature   Communications 2014, 5, 4269.

9. Y. Kadonaga, N.   Wang, Y. Fujimoto, K. Fukase Solid-phase synthesis of bacterial cell wall   peptidoglycan fragments. Chem. Lett. 2014, 43, 1461.

10. N. Wang, C.   Huang, M. Hasegawa, N. Inohara, Y. Fujimoto, K. Fukase Glycan   sequence-dependent Nod2 activation investigated with chemically synthesized   bacterial fragment library. ChemBioChem 2013, 14, 482.

11. N. Wang, L-H.   Zhang, X-S. Ye A new synthetic access to bicyclic polyhydroxylated alkaloid   analogues from pyranosides. Org. Biomol. Chem. 2010, 8,   2639.

12. Y. Niu, N. Wang,   X. Cao, X-S. Ye Efficient formation and cleavage of benzylidene acetals by   sodium hydrogen sulfate supported on silica gel. Synlett 2007, 13,   2116.

Book chapter:

1. 藤本ゆかり，Ambara R. Pradipta，Ning Wang，長谷川瑞穂、猪原直弘，深瀬浩一 Nod1/Nod2リガンドとしての細菌細胞壁ペプチドグリカン；化学合成と免疫調節活性. エンドトキシン・自然免疫研究 (16), 2013. (in Japanese)