Associate Professor

Tel: 0510-85197551

Email: Lizhou@jiangnan.edu.cn

2012 – present           Associate professor, Jiangnan University, School of Biotechnology

2005 – 2012               M.Sc. and Ph.D., Jiangnan University

2001 – 2005               B.Sc., Jiangnan University

Breeding of microorganism strain could improve production and   quality of a fermentation product, simplify fermentation process, reduce cost   and produce new product. The research work focused on construction of optimal   microorganisms for the production of amino acids, organic acids, bioactive   substances and enzymes using strategies concerning metabolic engineering,   synthetic biology, protein engineering and fermentation engineering, etc.

1.  Li Zhou,   Wen-Jing Cui, Zhong-Mei Liu, Zhe-Min Zhou. Metabolic engineering strategies for   D-lactate over production in Escherichia coli. Journal of Chemical Technology and Biotechnology, 2016, 91: 576-584

2.  Li Zhou, Can Deng, Wen-Jing Cui,   Zhong-Mei Liu, Zhe-Min Zhou. Efficient L-alanine production by a thermo-regulated   switch in Escherichia coli. Applied   Biochemistry and Biotechnology, 2016, 178: 324-337

3.  Longbao Zhu, Li Zhou   (co-first author), Nan Huang, Wen-Jing Cui, Zhong-Mei Liu, Ke Xiao, Zhe-Min   Zhou. Efficient preparation of enantiopure D-phenylalanine through asymmetric   resolution using immobilized phenylalanine ammonia-lyase from Rhodotorula   glutinis JN-1 in a recirculating packed-bed reactor. PLoS ONE, 2014, 9:   e108586

4.  Longbao Zhu, Li Zhou   (co-first author), Wen-Jing Cui, Zhong-Mei Liu, Zhe-Min Zhou. Mechanism-based   site-directed mutagenesis to shift the optimum pH of the phenylalanine   ammonia-lyase from Rhodotorula glutinis JN-1. Biotechnology Reports,   2014, 3: 21-26

5.  Kun Du, Zong-Mei Liu, Wen-Jing Cui, Li   Zhou, Yi Liu, Guo-Cheng Du, Jian Chen, Zhe-Min Zhou. A pH-dependent   activation of Streptomyces hygroscopicus transglutaminase mediated by   intein. Applied & Environmental Microbiology, 2014, 80: 723-729

6.  Xian-Zhong Chen, Li Zhou, Kang-Ming Tian,   Ashwani Kumar, Suren Singh, Bernard Prior, Zheng-Xiang Wang. Metabolic   engineering of Escherichia coli: a sustainable industrial platform for   bio-based chemical production. Biotechnology Advance, 2013, 31: 1200-1223

7.  Li Zhou, Xian-Zhong Chen, Dan-Dan Niu,   Kang-Ming Tian, Bernard A. Prior, Wei Shen, Gui-Yang Shi, Suren Singh,   Zheng-Xiang Wang. Genetically switched D-lactate production in Escherichia   coli. Metabolic Engineering, 2012, 14: 560-568

8.  Li Zhou, Wei Shen, Dan-Dan Niu, Kang-Ming   Tian, Bernard A. Prior, Gui-Yang Shi, Suren Singh, Zheng-Xiang Wang. Fine   tuning the transcription of ldhA for D-lactate production. Journal of   Industrial Microbiology & Biotechnology, 2012, 39: 1209-1217

9.  Li Zhou, Kang-Ming Tian, Dan-Dan Niu, Wei   Shen, Gui-Yang Shi, Suren Singh, Zheng-Xiang Wang. Improvement of D-lactate   productivity in recombinant Escherichia coli by coupling production   with growth. Biotechnology Letters, 2012, 34: 1123-1130

10.  Li Zhou, Zhi-Rui Zuo, Xian-Zhong Chen, Dan-Dan Niu,   Kang-Ming Tian, Bernard A. Prior, Wei Shen, Gui-Yang Shi, Suren Singh,   Zheng-Xiang Wang. Evaluation   of genetic manipulation strategies on D-lactate production by Escherichia   coli. Current Microbiology, 2011, 62: 981-989