Assoc. Prof. Jian-Zhong Xu

Tel: 15852834439

Email: xujianzhong@jiangnan.edu.cn/xujz126@126.com

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2017 – present  Associate Professor,   School of Biotechnology, Jiangnan University

2015 – 2017    Lecturer,   School of Biotechnology, Jiangnan University

2015 – 2017    Post-doctorate,   Jiangnan University-Shouguang Juneng Golden Corn Co., Ltd.

2011 – 2015    Ph.D.,   School of Biotechnology, Jiangnan University

2008 – 2011    M.Sc.,   School of Life Science, Fujian Agriculture and Forestry University

2004 – 2008      B.Sc., School of Material and Chemical Engineering, Jiangxi University   of Science and Technology

Microbial fermentation   processes hold many advantages over conventional chemical processes as   microbial fermentation provides more benefits such as selectivity, safety,   and cleanness. However, a high-producing strain is crucial to realize   industrial production by microbial fermentation. The Xu's   group is focused on constructing efficient cell for producing valuable fine   chemicals including amino acids, vitamin, and exopolysaccharide by metabolic   engineering and synthetic biology. In addition, They are also deeply   studied the metabolic control mechanism that leads to discovery   of novel modes of activation and inactivation, new regulatory motifs and   highly efficient fermentation process towards the production of the target   products. Representative academic discoveries include: L-lysine high-producing   strains, as one of the essential amino acids for animals and humans, were constructed   by optimizing the carbon metabolism pathway and/or intensifying the redox cofactors   availability; A menaquinone-7 high-producing strain was bred and the key   enzymes in biosynthetic pathway were analyzed. These related studies provide   a definite theoretical foundation for breeding high-yielding strains via   metabolic engineering and synthetic biology. They goal is to provide high-yielding   strains with proprietary intellectual property rights for manufacturer in our   country.

[1]   Jian Z. Xu^(*), Wei L. Yan and Wei G. Zhang, Enhancing   menaquinone-7 production in recombinant Bacillus amyloliquefaciens by   metabolic pathway engineering, RSC Advances, 2017, 7, 28527–28534.

[2]   Jian Z. Xu, and Wei G. Zhang^(*), Menaquinone-7 production   from maize meal hydrolysate by Bacillus isolates with diphenylamine   and analogue resistance, Journal of Zhejiang University-SCIENCE B   (Biomedicine & Biotechnology), 2017, 18(6):462-473.

[3]   Jian Z. Xu, Jun L. Zhang, Dong D. Liu, and Wei G. Zhang^(*),   Increased glucose utilization and cell growth of Corynebacterium   glutamicum by modifying the glucose specific phosphotransferase system   (PTS^Glc) genes, Canadian Journal of Microbiology, 2016, 62(12):   983-992。

[4]   Jian Z. Xu^(*), Jun L. Zhang, Mei Han, and Wei G. Zhang, A   method for simultaneous gene overexpression and inactivation in the Corynebacterium   glutamicum genome, Journal of Industrial Microbiology &   Biotechnology, 2016, 43(10): 1417-1427.

[5]   Jian Z. Xu, Mei Han, Xi D. Ren^(*), and Wei G. Zhang^(*),   Modification of aspartokinase III and dihydrodipicolinate synthetase   increases the production of L-lysine in Escherichia coli, Biochemical   Engineering Journal, 2016, 114: 82-89.

[6]   Jian Z. Xu, and Wei G.   Zhang^(*), The strategies used for genetically modifying bacteria   genome: site-directed mutagenesis, gene inactivation and gene over-expression,   Journal of Zhejiang   University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(2):   83-99.

[7]   Gong Chen, Jian Z. Xu^(*), Xiu H. Xia, Yan F. Guo, Kai Xu,   Cun S. Sun, and Wei G. Zhang^(*), Breeding L-arginine-producing   strains by a novel mutagenesis method: Atmospheric and room temperature   plasma (ARTP), Preparative Biochemistry &   Biotechnology, 2016, 46(5): 509-516.

[8]   Jian Z. Xu, Jun L. Zhang, Yan F. Guo, and Wei G. Zhang^(*),   Genetically modifying aspartate aminotransferase and aspartate ammonia-lyase   affects metabolite accumulation in L-lysine producing strain derived from Corynebacterium   glutamicum ATCC13032, Journal of Molecular   Catalysis B: Enzymatic, 2015, 113: 82-89.

[9]   Jian Z. Xu, Mei Han, Jun L. Zhang, Yan F. Guo, and Wei G. Zhang^(*),   Metabolic engineering Corynebacterium glutamicum for the L-lysine   production by increasing the flux into L-lysine biosynthetic pathway, Amino   Acids, 2014, 46(9): 2165-2175.

[10]   Jian Z. Xu, Mei Han, Jun L. Zhang, Yan F. Guo, He Qian, and Wei G.   Zhang^(*), Improvement of L-lysine production combines with   minimization of by-products synthesis in Corynebacterium glutamicum, Journal   of Chemical Technology & Biotechnology, 2014, 89(12): 1924-1933.

[11]   Jian Z. Xu, Xiu H. Xia, Jun L. Zhang, Yan F. Guo, He Qian, and Wei G.   Zhang^(*), A method for gene amplification and simultaneous   deletion in Corynebacterium glutamicum genome without any genetic   markers, Plasmid, 2014, 72: 9-17.

[12]   Jian Z. Xu,   Xiu H. Xia, Jun L. Zhang, Yan F. Guo, He Qian, and Wei G. Zhang^(*),   An overlooked effect of glycine betaine on fermentation: prevents   caramelization and increases the L-lysine production, Journal of Microbiology   and Biotechnology, 2014, 24(10): 1380-1388.

[13]   Jian Z. Xu^(*), Jun L. Zhang, Yan F. Guo, Quan D. Jia, and   Wei G. Zhang, Heterologous expression of Escherichia coli fructose-1,6-bisphosphatase   in Corynebacterium glutamicum and evaluating the effect on cell growth   and L-lysine production, Preparative Biochemistry &   Biotechnology, 2014, 44(5): 493-509.

[14]   Jian Z. Xu^(*), Jun L. Zhang, Yan F. Guo, Yui G. Zai, and   Wei G. Zhang, Improvement of cell growth and   L-lysine production by genetically modified Corynebacterium glutamicum   during growth on molasses, Journal of Industrial Microbiology &   Biotechnology, 2013, 40(12): 1423-1432.

[15]   Jian Z. Xu, Jun L. Zhang, Kai H. Hu^(*), and Wei G. Zhang^(*),   The relationship between lignin peroxidase and manganese peroxidase   production capacities and cultivation periods of mushrooms, Microbial Biotechnology, 2013,   6(3): 241-247.

[16]   Jian Z. Xu, Jun L. Zhang, Wei G. Zhang^(*), and Kai H. Hu^(*),   The novel role of fungal intracellular laccase: used to screen hybrids   between Hypsizigus marmoreus and Clitocybe maxima by   protoplasmic fusion, World Journal of Microbiology &   Biotechnology, 2012, 28(8): 2625-2633.