Associate Professor

Tel: 86-510-85918106

Email: xylu@jiangnan.edu.cn

Web:

2017 – present   Associate Professor,   Jiangnan University, School of Biotechnology.

2013 – 2017     Lecture,   Jiangnan University, School of Biotechnology.

2008 - 2013     Ph.D, Jiangnan   University, School of Biotechnology.

2004 – 2008     B.E., Yangzhou   University

Main research   interesting on these areas, Synthetic biology and enzyme engineering,

1.    Biosynthesis   of polyols by metabolic engineering and synthetic biology, including:   1,3-propanediol, 3-hydroxy propionic acid, 1,2,4- butantriol.

2.    Exploring the   mechanism responsible for the excellent stress tolerance of industrial yeast

3.    Development   of genetic manipulation tools for engineering industrial diploid yeast

4.    Enzyme   expression, modification, and application.

1. Xinyao Lu, Song Liu, Dongxu Zhang,   Xiaoman Zhou, Miao Wang, Yi Liu, Jing Wu, Guocheng Du, Jian Chen “Enhanced   thermal stability and specific activity of Pseudomonas aeruginosa   lipoxygenase by fusing with self-assembling amphipathic peptides” Appl   Microbiol Biotechnol (2013) 97:9419–9427

2. Xinyao Lu, Song Liu, Yue Feng, Shengqi   Rao, Xiaoman Zhou, Miao Wang, Guocheng Du & Jian Chen “Enhanced thermal stability of Pseudomonas   aeruginosa lipoxygenase through modification of two highly flexible   regions” Appl Microbiol Biotechnol (2014)   98:1663–1669

3. Xinyao Lu, Juan Zhang, Song Liu,   Dongxu Zhang, Zhi Xu, Jing Wu, Jianghua Li, Guocheng Du &Jian Chen “Overproduction, purification, and characterization   of extracellular lipoxygenase of Pseudomonas aeruginosa in Escherichia   coli.”Industrial Appl Microbiol Biotechnol 2013   , 97 (13) :5793-5800

4. Xinyao Lu, Shuying He, Hong Zong, Jian   Song, Wen Chen, Bin Zhuge “Improved 1, 2,   4-butanetriol production from an engineered Escherichia coli by   co-expression of different chaperone proteins” World   J Microbiol Biotechnol (2016) 32:149

5. Xinyao Lu, Xiaomeng Fu, Hong Zong, and   Bin Zhuge “Overexpressions of xylA and xylB in   Klebsiella pneumoniae Lead to Enhanced 1,3-Propanediol Production by   Cofermentation of Glycerol and Xylose” J.   Microbiol. Biotechnol. (2016), 26(7), 1252–1258

6. Xinyao Lu, Guangsheng Wang, Yue Feng,   Song Liu, Xiaoman Zhou, Guocheng Du, and Jian Chen “The N-Terminal α-Helix Domain of Pseudomonas   aeruginosa Lipoxygenase Is Required for Its Soluble Expression in Escherichia   coli but Not for Catalysis” J.   Microbiol. Biotechnol. (2016), 26(10), 1701–1707

7. Xinyao Lu, Guangjian Ji, Hong Zong   & Bin Zhuge “The role of budABC on 1,3-propanediol and   2,3-butanediol production from glycerol in Klebsiella pneumoniae CICIM   B0057” Bioengineered 2016

8. Xinyao Lu, Yuqin Wang, Hong Zong, Hao   Ji, Bin Zhuge & Zhuoli Dong“Bioconversion   of L-phenylalanine to 2-phenylethanol by the novel stress-tolerant yeast Candida   glycerinogenes WL2002-5” Bioengineered 2016

9. X.Y. Lu, S.L. Ren, J.Z. Lu, H. Zong,   J. Song and B. Zhuge “Enhanced 1,3-propanediol production in   Klebsiella pneumoniae by a combined strategy of strengthening the TCA cycle   and weakening the glucose effect”J Appl   Microbiol, 2018 124, 682--690