Fei Xu

Professor

School of Biotechnology, Jiangnan University

No. 1800 Lihu Ave., Wuxi, China

Tel: 86-0510-85328817

Email: feixu@jiangnan.edu.cn

Web: 

2015 –present   Professor, School of Biotechnology, Jiangnan University 

2007 – 2014     Postdoctoral Fellow/Research Associate, Centre for Biotechnology and Medicine, Rutgers University

2004 – 2007       Graduate Assistant, Department of Chemistry, Rutgers University

2001 – 2004       Teaching Assistant, General Chemistry Lab and Organic Chemistry Lab, Rutgers University

2003 – 2006       Minor: M.Sc., Food Chemistry, Rutgers, the State University of New Jersey

2000 – 2007       Major: PhD, Biochemistry/Computational Biology, Rutgers, the State University of New Jersey

1996 – 2000        B.Sc., BiologyTalented Program, Wuhan University

Computational modeling and Experimental Biophysics of biological macromolecules with certain properties and functions by and experimental verification:

(1) computational design fibrin biomaterials, such as collagen；

(2) flexibility of fibrin molecules；

(3) Industrial enzyme engineering.

2015-present：

[1]. H., Zheng, Lu, J. Lan, S. Fan*, V. Nanda*, and F. Xu*, How electrostatic networks modulate specificity and stability of collagen. Proc. Natl. Acad. Sci. U. S. A., 2018. 115(24): p. 201802171.

[2].H. Zheng, H. Liu, J. Hu, and F. Xu*, Stabilizing effects of pairwise salt bridges between acidic and basic residues in a collagen heterotrimer. Chem. Phys. Lett., 2018. 713: p. 253-258.

[3] Y., Li, H. Yang, and F. Xu*, Identifying and engineering a critical amino acid residue to enhance the catalytic efficiency of Pseudomonas sp. methyl parathion hydrolase. Appl. Microbiol. Biot., 2018. 102(15): p. 6537-6545.

[4]. F., Xu*, H., Zheng, N., Clauvelin, X.-J, Lu, W.K., Olson*, V., Nanda*, Parallels between DNA and collagen - comparing elastic models of the double and triple helix. Sci. Rep., 2017, 7:12802.

2010-2015:

[1]. Xu Fei, Khan, I. J., McGuinness, K., Parmar, A. S., Silva, T., Murthy, S., Nanda, V., Self-assembly of left and right-handed molecular screws, J. Am. Chem. Soc., 2013, 135: 18762-18765

[2]. Xu Fei, Silva, T., Joshi, M., Zahid, S., Nanda, V., Circular Permutation Directs Orthogonal Assembly in Complex Collagen Peptide Mixtures, J. Biol. Chem., 2013, 288:31616-31623

[2].Xu Fei, Li, J., Jain, V., Tu, R., Huang, Q., Nanda, V., Compositionally Controlled Collagen Peptide Self-Assembly and Fiber Morphology, J. Am. Chem. Soc., 2012, 134:47-50

[3].Xu Fei, Zahid, S., Silva, T., Nanda, V., Computational Design of a Collagen A:B:C-type Heterotrimer, J. Am. Chem. Soc., 2011, 133:15260-15263

[4].Xu Fei, Colasanti, A., Li, Y., Olson, W. K., Long-range effects of histone point mutations on DNA remodeling revealed from computational analyses of SIN-mutant nucleosome structures, Nucleic Acids Research, 2010, 38:6872-82

[8].Xu Fei, Zhang, L., Koder, R., and Nanda, V., De novo self-assembling collagen heterotrimers using explicit positive and negative design. Biochemistry. 2010, 49, 2307-2316

[9].Xu Fei, and Olson, W. K., DNA architecture, deformability, and nucleosome positioning. J. Biomol. Struct. & Dyn.. 2010, 27(6), 725-739