Xiaoyuan Wang

Professor  

Tel: 0510-85329329

Email: xwang@jiangnan.edu.cn

2007-present   Professor, Jiangnan University

2003-2007     Senior Research Associate, Duke University

2000-2003     Research Fellow, UT-Houston Medical School

1997-2000     Ph.D., University of London

1992-1997     Assistant Professor, Tsinghua University

1989-1992     M.Sc., Tsinghua University

1987-1989     Assistant Professor, Taiyuan Industrial University

1983-1987     B.Sc., Shanxi Normal University 

1. Metabolic engineering of bacteria to produce amino acids.

2. Global regulation in bacteria.

3. Analysis and removal of endotoxins.

4. Detection and control of food borne pathogens.   

Books   

1. Wang X, Chen J and Quinn PJ. (Eds.) (2012) Reprogramming Microbial Metabolic Pathways. Subcell Biochem 64. Springer.

2. Wang X and Quinn PJ. (Eds.) (2010) Endotoxins: Structure, Function and Recognition. Subcell Biochem. 53. Springer. 

3. Quinn PJ and Wang X. (Eds.) (2008) Lipids in Health and Disease. Subcell Biochem, Vol. 49. Springer.

Chapters and Reviews  

1. Wang X and Quinn PJ. (2017) Metabolic Engineering of Corynebacterium glutamicum for L-Valine Production. The Handbook of Microbial Metabolism of Amino Acids. CAB International. 223-233. (Chapter)

2. Wang X and Quinn PJ. (2010) Endotoxins: Lipopolysaccharides of Gram-negative Bacteria. Subcell Biochem 53, 2-36. (Chapter)

3. Wang X, Zhang C, Shi F and Hu X. (2010) Purification and Characterization of Lipopoolysaccharides. Subcell Biochem 53, 37-72. (Chapter)

4. Dong X, Quinn PJ, Wang X. (2012) Microbial Metabolic Engineering for L-Threonine Production. Subcell Biochem 64, 283-302. (Chapter)

5. Hu X, Quinn PJ, Wang Z, Han G and Wang X. (2012) Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis. Subcell Biochem 64, 327-342. (Chapter)

6. Wang X, Quinn PJ, Yan A. (2015) Kdo2 -lipid A: structural diversity and impact on immunopharmacology. Biol Rev Camb Philos Soc. 90, 408–427. (Review) 

7. Dong X, Quinn PJ, Wang X. (2011) Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the production of L-threonine. Biotechnol Adv. 29, 11-23. (Review) 

8. Wang X and Quinn PJ. (2010) Lipopolysaccharide: Biosynthetic Pathway and Structure Modification. Prog Lipid Res. 49, 97-107. (Review) 

9. Wang X and Quinn PJ. (2000) The location and function of vitamin E in membranes. Mol Membr Biol, 17, 143-156. (Review)

10. Wang X and Quinn PJ. (1999) Vitamin E and its function in membranes. Prog Lipid Res, 38, 309-336. (Review)

Research Papers

1. Chen C, Li Y, Hu J, Dong X, Wang X. Metabolic engineering of Corynebacterium glutamicum ATCC13869 for l-valine production. Metab Eng. 2015;29:66-75.

2. Li Y, Powell D, Shaffer SA, Rasko DA, Pelletier MR, Leszyk J, Scott A, Masoudi A, Goodlett D, Wang X, Raetz CR, Ernst RK. (2012) LPS remodeling is an evolved survival strategy for bacteria. Proc Natl Acad Sci U S A. 109(22):8716-21.

3. Yin L, Hu X, Xu D, Ning J, Chen J, Wang X. (2012) Co-expression of feedback-resistant threonine dehydratase and acetohydroxy acid synthase increase L-isoleucine production in Corynebacterium glutamicum. Metab Eng. 14(5):542-50.  

4. Dong X, Quinn PJ, Wang X. (2011) Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the production of L-threonine. Biotechnol Adv. 29, 11-23.  

5. Wang X, Ribeiro A, Guan Z and Raetz CR. (2009) Identification of Undecaprenyl Phosphate-β-D-Galactosamine in Francisella novicida and Its Function in Lipid A Modification. Biochemistry. 48, 1162–1172.  

6. Wang X, Ribeiro A, Guan Z, Abraham S & Raetz CR. (2007) Attenuated Virulence of a Francisella Mutant Lacking the Lipid A 4′-Phosphatase. Proc. Natl. Acad. Sci. U S A. 104, 4136-4141.

7. Wang X, Ribeiro A, Guan Z, McGrath S, Cotter R & Raetz CR. (2006) Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida. Biochemistry 45, 14427-14440.

8. Wang X, McGrath SC, Cotter RJ, Raetz CR. (2006) Expression Cloning and Periplasmic Orientation of the Francisella novicida Lipid A 4′-Phosphatase LpxF. J. Biol. Chem. 281:9321-9330.  

9. Wang X, Karbarz MJ, McGrath SC, Cotter RJ, Raetz CR. (2004) MsbA transporter dependent lipid A 1-dephosphorylation on the periplasmic surface of the inner membrane:Topography of Francisella novicida LpxE expressed in Escherichia coli. J. Biol. Chem. 279, 49470-49478.

10. Wang X, Bogdanov M and Dowhan W. (2002) Topology of polytopic membrane protein subdomains is dictated by membrane phospholipid composition. EMBO J, 21, 5673-5681.