Zhonghu Bai

Professor

Tel: +8651085197983

Email: baizhonghu@jiangnan.edu.cn

Web: 

Education Background:

Ø 1983-1987: Chemical Engineering ,Zhejiang Univ., B.Sc., Hangzhou, , Zhejiang, PR China

Ø 1987-1989: Henan Academy of Sciences, research assistant, Zhengzhou, Henan, PR China

Ø 1989-1992: Biochemical Engineering, Tsinghua Univ., M.Sc., Beijing, PR China

Ø 1992-1999: Biocell Co Ltd. Senior scientist, R&D director, Zhengzhou, Henan, PR China

Ø 1999-2002: Strathclyde Univ., Bioscience, Ph.D., Glasgow, Scotland, UK

Ø 2002/10: Oxford Univ. Biological Chemistry, Postdoc., Oxford, UK

Ø 2002- 2005:  Imperial College London, Exp. Medicine, Post.doc., London, UK

Working Experience:

Ø 2005-2006: GlaxoSmithKline, BioPharm R&D, Research fellow, London, UK

Ø 2006-2008: Ortho Clinical Diagnostics, Johnson & Johnson, Senior investigator, Cardiff, Wales, UK

Ø 2008-2012: GlaxoSmithKline, BioPharm R&D, Principal Investigator, Stevenage, England, UK

Ø  2012- present：National Engineering Laboratory for Cereal Fermentation Technology, Biotechnology School, Jiangnan Univ. Wuxi，PR China

Prof. Z Bai set up his group in Jiangnan University in Sept. 2012. Since then his group has been focusing on filling the gap between China and developed countries in the areas of methodology, innovative technology, and QbD principle of bioprocess research/development for biopharmaceutical industry. His group has conducted serval projects funded by Chinese central government (863 and 973 program), Jiangsu province and some leading public companies of China in biopharmaceutical industry, aiming at supporting Chinese biopharmaceutical community to synchronize with the contemporaries of advanced countries in terms of technology and concept of biopharmaceutical process engineering. At the present, the ongoing projects running in this group include: 1) Bioprocess research of microbial fermentation for recombinant protein expression. 2) QbD driven bioprocess research of cell cultures at bioreactor scale for biopharmaceutics production, e.g. antibody, vaccine, and genetic modified T cell. 3) Study on molecular microbiology towards the establishment of innovative host cells and relevant genetic components for recombinant protein expression. 4) Design and validation of bioreactors for mammalian cell cultures from miniature to pilot scale. 5) Development of high throughput cultivation technology platform.

1) Xiaofeng Dai; Xiao Chen; Qiuwu Fang; Jia Li; Zhonghu Bai. Inducible CRISPR genome-editing tool: classifications and future trends. Critical Reviews in Biotechnology. Crit Rev Biotechnol. 2018 ,38(4):573-586

2) Li X; Yang Y; Zhan C; Zhang Z; Liu X; Liu H; Bai Z. Transcriptional analysis of impacts of glycerol transporter 1 on methanol and glycerol metabolism in Pichia pastoris. FEMS yeast research. 2018, 18(1).

3) Xiuxia Liu, Wei Zhang, Zihao Zhao, Xiaofeng Dai, Yankun Yang(*), Zhonghu Bai(*),Protein secretion in Corynebacterium glutamicum. Critical Reviews in Biotechnology, 2017, 37(4):541-551.

4) Xiuxia Liu, Yangsun, Fen Wang, Xiaofeng Dai, Yankun Yang, Zhonghu Bai1. Comparative analysis of the Corynebacterium glutamicum transcriptome in response to changes in dissolved oxygen levels. Journal of Industrial Microbiology & Biotechnology, 2017, 44(2):181-195.

5) Zhan C; Yang Y; Zhang Z; Li X; Liu X; Bai Z. Transcription factor Mxr1 promotes the expression of Aox1 by repressing glycerol transporter 1 in Pichia pastoris. FEMS yeast research. 2017, 17(4).

6) Yang Sun, Wenwen Guo, Fen Wang, Chunjun Zhan, Yankun Yang, Xiuxia Liu, Zhonghu Bai. Transcriptome analysis of Corynebacterium glutamicum in the process of recombinant protein expression in bioreactors. Plos one, 2017, 12(4):1-18.

7) Xiaofeng Dai, Hongye Cheng, Zhonghu Bai, Jia Li. Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping. Journal of Cancer. 2017; 8(16): 3131-3141.

8) Xiuxia Liu; Zihao Zhao; Wei Zhang; Yang Sun; Yankun Yang and Zhonghu Bai. Bicistronic expression strategy for high-level expression of recombinant proteins in Corynebacterium glutamicum. Engineering in Life Sciences. 2017; 17(10):1118-1125.

9) Peng F, Wang X, Sun Y, Dong G, Yang Y, Liu X*, Bai Z*. Efficient gene editing in Corynebacterium glutamicum using the CRISPR/Cas9 system. Microb Cell Fact. 2017, 16(1):201.

10) Zhang W; Zhao Z; Yang Y; Liu X; Bai Z. Construction of an expression vector that uses the aph promoter for protein expression in Corynebacterium glutamicum. Plasmid. 2017,94:1-6