Weiguo Zhang

Professor

Tel: 0086-13861775899

Email: zhangwg@jiangnan.edu.cn

Web: 

2002 – present  Professor, School of Biotechnology, Jiangnan University

1996 – 2001    Doctor of Engineering, School of Biotechnology, Jiangnan University

1987 – 1989    M. En., School of Biotechnology, Wuxi University of Light Industry

1984 – 1987    Jiangsu Institute of Food fermentation

1980– 1984     B. En., Wuxi Institute of Light Industry

Research interests: fermentation engineering, industrial microorganism breeding (amino acid producing bacteria breeding and industrial production). Key achievements: lead the completion of the national 863 goal-oriented project L- valine efficient clean fermentation production key technology research (2008AA02Z212); To complete the development and research of national 863 bulk product, which is a sub-project of the breeding and process optimization control technology of high-yield glutamic acid fermentation strain, the breeding of high-yield glutamic acid fermentation strain and the study of metabolic network (2006AA020301-10); Presided over the completion of the State Economic and Trade Commission production and research projects-100 tons of medicinal grade L- isoleucine and L- valine annually; presided over the completion of the Ministry of provincial science and technology projects 6, science and technology transfer projects 12. The production of L-isoleucine, L-valine, L-lysine and threonine by fermentation has reached the leading level at home and abroad. Transfer of Amino Acid production Technology to Meihua Group, Fufeng Group, Xinghu Science and Technology, Cofco Biochemistry and other domestic enterprises and international top 500 enterprises such as Degussa of Germany (transfer of 4 amino acids), ADM of the United States (transfer of 3 amino acids), Korea CJ Company (transfer of 2 amino acids) and Ajnomoto of Japan (transfer of 1 amino acid).

1. Li-Yan Feng, Jian-Zhong Xu, Wei-Guo Zhang. Improved L-Leucine Production in Corynebacterium glutamicum by Optimizing the Aminotransferases. Molecules 2018, 23, 2102

2. Jian-zhong XU, Jun-lan ZHANG, Wei-guo ZHANG. Antisense RNA: the new favorite in genetic research Univ-Sci B (Biomed & Biotechnol). 2018 19(10):739-749

3. Jian-Zhong Xu, Han-Kun Yang & Wei-Guo Zhang. NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis. CRITICAL REVIEWS IN BIOTECHNOLOGY 2018, VOL. 38, NO. 7, 1061–1076

4. Jian-Zhong Xu, Han-Kun Yang, Wei-Guo Zhang. NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis. CRITICAL REVIEWS IN BIOTECHNOLOGY 2018, VOL. 38, NO. 7, 1061–1076

5. Jian‑Zhong Xu, Ze‑Hua Wu, Shi‑Jun Gao, Weiguo Zhang. Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum. Microb Cell Fact (2018) 17:105

6. Jian-Zhong Xu, Wei-Liu Yan, Wei-Guo Zhang. Enhancing menaquinone-7 production in recombinant Bacillus amyloliquefaciens by metabolic pathway engineering RSC Adv., 2017, 7, 28527–28534

7. Jianzhong Xu, Junlan Zhang, Dongdong Liu, Weiguo Zhang. Increased glucose utilization and cell growth of Corynebacterium glutamicum by modifying the glucose-specific phosphor- transferase system (PTS Glc ) genes Can. J. Microbiol. Vol. 62, 2016

8. Jian-zhong XU, Wei-guo ZHANG. Menaquinone-7 production from maize meal hydrolysate byBacillus isolates with diphenylamine and analogue resistance. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2017 18(6):462-473

9. Jianzhong Xu,·Junlan Zhang, Mei Han, Weiguo Zhang. A method for simultaneous gene overexpression and inactivation in the Corynebacterium glutamicum genome. J Ind Microbiol Biotechnol (2016) 43:1417–1427

10. Jian-Zhong Xu, Han-Kun Yang, Li-Ming Liu, Ying-Yu Wang, Wei-Guo Zhang. Rational modification of Corynebacterium glutamicum dihydrodipicolinate reductase to switch the nucleotide-cofactor specificity for increasing L-lysine production. Biotechnology and Bioengineering 2018